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Article

An exactly solvable, spatial model of mutation accumulation in cancer.

Scientific reports - 22 Dec 2016

Paterson Chay, Nowak Martin A, Waclaw Bartlomiej

Abstract excerpt

One of the hallmarks of cancer is the accumulation of driver mutations which increase the net reproductive rate of cancer cells and allow them to spread. This process has been studied in mathematical models of well mixed populations, and in computer simulations of three-dimensional spatial models. But the computational complexity of these more realistic, spatial models makes it difficult to simulate realistically...

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Identifiers

PMID: 28004754
DOI: 10.1038/srep39511
PMCID: PMC5177951

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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