Article

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR <sub>B</sub> GTPase domain

2022-06-09

Abstract excerpt

Leucine-rich-repeat-kinase 1 (LRRK1) and its homologue LRRK2 are multidomain kinases possessing a ROC-COR A -COR B containing GTPase domain and phosphorylate distinct Rab proteins. LRRK1 loss of function mutations cause the bone disorder osteosclerotic metaphyseal dysplasia, whereas LRRK2 missense mutations that enhance kinase activity cause Parkinson’s disease. Previous work suggested that LRRK1 but not LRRK2,...

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Literature Corpus work: ee876933-3ebd-574a-a773-57a66ec6cff4
DOI: 10.1101/2022.06.09.495448

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PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR <sub>B</sub> GTPase domainDOI 10.1101/2022.06.09.495448Read

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