Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner.

Cell death & disease - 17 Oct 2024

Iannotta Lucia, Fasiczka Rachel, Favetta Giulia, Zhao Yibo, Giusto Elena, Dall'Ara Elena, Wei Jianning, Ho Franz Y, Ciriani Claudia, Cogo Susanna, Tessari Isabella, Iaccarino Ciro, Liberelle Maxime, Bubacco Luigi, Taymans Jean-Marc, Manzoni Claudia, Kortholt Arjan, Civiero Laura, Hilfiker Sabine, Lu Michael L, Greggio Elisa

Abstract excerpt

P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the physiological function of the kinase in the context of brain cells is poorly understood. Our previous work uncovered a link between PAK6 and the Parkinson's disease (PD)-associated...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Astrocytes
Share to Centrosome

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HEK293 Cells

Share to Leucine-Rich Repeat Serine-Threonine Protein Kinase-2

Share to Neurons

Share to p21-Activated Kinases

Share to Parkinson Disease

Source

Open in PubMed Open full text

Identifiers

PMID: 39419978
DOI: 10.1038/s41419-024-07124-4
PMCID: PMC11487180

Genes

PAK6

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner.PMID 39419978Read ↗

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific mannerSemantic proximity Read ↗

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific mannerSemantic proximity Read ↗

Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain.Semantic proximity Read ↗

RAB12-LRRK2 complex suppresses primary ciliogenesis and regulates centrosome homeostasis in astrocytes.Semantic proximity Read ↗

RAB12-LRRK2 Complex Suppresses Primary Ciliogenesis and Regulates Centrosome Homeostasis in AstrocytesSemantic proximity Read ↗

LRRK2 regulates ArfGAP1 membrane localization, activity and neuronal toxicity via phosphorylation within its lipid-sensing ALPS2 motifSemantic proximity Read ↗

Parkinson disease-associated mutations in LRRK2 cause centrosomal defects via Rab8a phosphorylationSemantic proximity Read ↗

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the COR <sub>B</sub> GTPase domainSemantic proximity Read ↗

In silico comparative analysis of LRRK2 interactomes from brain, kidney and lung.Semantic proximity Read ↗

The LRRK2 signaling network converges on a centriolar phospho-Rab10/RILPL1 complex to cause deficits in centrosome cohesion and cell polarizationSemantic proximity Read ↗

Proximity proteomics reveals a co-evolved LRRK2-regulatory network linked to centrosomesSemantic proximity Read ↗

PKC isoforms activate LRRK1 kinase by phosphorylating conserved residues (Ser1064, Ser1074 and Thr1075) within the CORB GTPase domain.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.