Article

PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner

2024-04-14

Abstract excerpt

P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the physiological function of the kinase in the context of brain cells is poorly understood. Our previous work uncovered a link between PAK6 and the Parkinson's disease (PD)-associated...

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Literature Corpus work: 402c05d6-7e53-51e8-9f10-3b5dc256fff9
DOI: 10.1101/2024.04.11.589075

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PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific mannerDOI 10.1101/2024.04.11.589075Read

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