Article

Identification of two novel DnaJ chaperone family proteins as modifiers of Huntingtin aggregates

2023-11-02

Abstract excerpt

Huntington’s disease (HD) is a rare neurodegenerative disease. It is caused due to aggregation of Huntingtin (HTT) protein containing Q repeats more than 40. Similar protein aggregation is also a hallmark of several other neurodegenerative diseases related to loss of cognitive function. In search of modifiers of HTT aggregation, we have screened putative chaperone proteins from Drosophila in both fly and yeast mo...

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Literature Corpus work: ee854a46-4d90-58ac-b856-7b9a5a19eb1e
DOI: 10.1101/2023.10.31.564873

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