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Article

A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.

Genetics - 1 Apr 2010

Zhang Sheng, Binari Richard, Zhou Rui, Perrimon Norbert

Abstract excerpt

Protein aggregates are a common pathological feature of most neurodegenerative diseases (NDs). Understanding their formation and regulation will help clarify their controversial roles in disease pathogenesis. To date, there have been few systematic studies of aggregates formation in Drosophila, a...

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Identifiers

PMID: 20100940
DOI: 10.1534/genetics.109.112516
PMCID: PMC2865916

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20100940-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A genomewide RNA interference screen for modifiers of aggregates formation by mutant Huntingtin in Drosophila.PMID 20100940Read ↗

RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation.Semantic proximity Read ↗

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Identification of genes that modify ataxin-1-induced neurodegeneration.Semantic proximity Read ↗

Identification of two novel DnaJ chaperone family proteins as modifiers of Huntingtin aggregatesSemantic proximity Read ↗

Juvenile and adult expression of polyglutamine expanded <i>huntingtin</i> produce distinct aggregate distributions in <i>Drosophila</i> muscleSemantic proximity Read ↗

The ubiquitin thioesterase YOD1 ameliorates mutant Huntingtin induced pathology in Drosophila.Semantic proximity Read ↗

Mechanisms of chaperone suppression of polyglutamine disease: selectivity, synergy and modulation of protein solubility in Drosophila.Semantic proximity Read ↗

Identification of NUB1 as a suppressor of mutant Huntington toxicity via enhanced protein clearance.Semantic proximity Read ↗

Drosophila Models of Tauopathies: What Have We Learned?Semantic proximity Read ↗

Aggregation of huntingtin in yeast varies with the length of the polyglutamine expansion and the expression of chaperone proteins.Semantic proximity Read ↗

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