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A Review On Huntington Protein: Insight Into Protein Aggregation and Therapeutic Interventions.

Current drug metabolism - 1 Jan 2022

Srinivasan Ekambaram, Ram Vavish, Rajasekaran Ramalingam

Abstract excerpt

Huntington's disease (HD) is a distressing, innate neurodegenerative disease that descends from CAG repeat expansion in the huntingtin gene causing behavioral changes, motor dysfunction, and dementia in children and adults. Mutation in huntingtin (HTT) protein has been suggested to cause neuron loss in the cortex and striatum through various mechanisms, including abnormal regulation of transcription, proteasomal...

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PMID: 35319359
DOI: 10.2174/1389200223666220321103942

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