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Article

RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation.

PloS one - 30 Sept 2009

Doumanis Joanna, Wada Koji, Kino Yoshihiro, Moore Adrian W, Nukina Nobuyuki

Abstract excerpt

The fruitfly Drosophila melanogaster is well established as a model system in the study of human neurodegenerative diseases. Utilizing RNAi, we have carried out a high-throughput screen for modifiers of aggregate formation in Drosophila larval CNS-derived cells expressing mutant human Huntingtin exon 1 fused to EGFP with an expanded polyglutamine repeat (62Q). 7200 genes, encompassing around 50% of the Drosophila...

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Identifiers

PMID: 19789644
DOI: 10.1371/journal.pone.0007275
PMCID: PMC2748703

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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