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eccDNA purification, full-length sequencing, and genomic mapping

2022-06-17

Abstract excerpt

Extrachromosomal circular DNA (eccDNA) has been discovered for more than half a century 1 . However, its biogenesis and function have just begun to be elucidated. One hurdle that prevented our understanding of eccDNA is the difficulty in obtaining pure eccDNA from cells. The current eccDNA purification methods mainly rely on exonuclease digestion after alkaline lysis. Due to its low abundance and heterogeneity in...

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Literature Corpus work
ea19e42d-60f6-5702-9142-d52913958311
DOI
10.1101/2022.06.15.496131
Open publication

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eccDNA purification, full-length sequencing, and genomic mappingDOI 10.1101/2022.06.15.496131
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