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Article

Noncoding RNA processing by DIS3 regulates chromosomal architecture and somatic hypermutation in B cells.

Nature genetics - 1 Feb 2021

Laffleur Brice, Lim Junghyun, Zhang Wanwei, Chen Yiyun, Pefanis Evangelos, Bizarro Jonathan, Batista Carolina R, Wu Lijing, Economides Aris N, Wang Jiguang, Basu Uttiya

Abstract excerpt

Noncoding RNAs are exquisitely titrated by the cellular RNA surveillance machinery for regulating diverse biological processes. The RNA exosome, the predominant 3' RNA exoribonuclease in mammalian cells, is composed of nine core and two catalytic subunits. Here, we developed a mouse model with a conditional allele to study the RNA exosome catalytic subunit DIS3. In DIS3-deficient B cells, integrity of the...

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Identifiers

PMID: 33526923
DOI: 10.1038/s41588-020-00772-0
PMCID: PMC8011275

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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