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Article

A compendium of DIS3 mutations and associated transcriptional signatures in plasma cell dyscrasias.

Oncotarget - 22 Sept 2015

Lionetti Marta, Barbieri Marzia, Todoerti Katia, Agnelli Luca, Fabris Sonia, Tonon Giovanni, Segalla Simona, Cifola Ingrid, Pinatel Eva, Tassone Pierfrancesco, Musto Pellegrino, Baldini Luca, Neri Antonino

Abstract excerpt

DIS3 is a catalytic subunit of the human exosome complex, containing exonucleolytic (RNB) and endonucleolytic (PIN) domains, recently found mutated in multiple myeloma (MM), a clinically and genetically heterogeneous form of plasma cell (PC) dyscrasia. We analyzed by next-generation sequencing (NGS) the DIS3 PIN and RNB domains in purified bone marrow PCs from 164 representative patients, including 130 cases with...

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Share to Disease Progression
Share to Exosome Multienzyme Ribonuclease Complex

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Gene Ontology

Share to High-Throughput Nucleotide Sequencing

Share to Multiple Myeloma

Share to Paraproteinemias

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 26305418
DOI: 10.18632/oncotarget.4674
PMCID: PMC4694891

Genes

DIS3
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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