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Article

The molecular spectrum and clinical impact of DIS3 mutations in multiple myeloma.

British journal of haematology - 1 Apr 2015

Weißbach Susann, Langer Christian, Puppe Bernhard, Nedeva Theodora, Bach Elisa, Kull Miriam, Bargou Ralf, Einsele Hermann, Rosenwald Andreas, Knop Stefan, Leich Ellen

Abstract excerpt

Multiple myeloma (MM) is a plasma cell neoplasm that presents with a major biological and clinical heterogeneity. We here investigated the spectrum of clonal and subclonal mutations of DIS3, an active part of the exosome complex, that may play a role in the development or progression of MM. The whole coding sequence of DIS3 was subjected to deep sequencing in 81 uniformly-treated MM patients and 12 MM cell lines...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25521164
DOI: 10.1111/bjh.13256

Genes

DIS3
IGH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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