Lysosomal swelling triggers LRRK2 activity

Abstract excerpt

LRRK2 is implicated in lysosomal functions, but the physiological upstream cues that engage endogenous LRRK2 activity are incompletely defined. Here we show that lysosomal swelling serves as a selective and reversible trigger for LRRK2-mediated Rab phosphorylation, without requiring membrane damage. Acute inhibition of PIKfyve, but not the general disruption of phosphoinositide signaling, induces the robust accumu...

Topics

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• Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
• Lysosomes
• Mutation
• Parkinson Disease
• Phosphorylation
• Protein Transport
• Proteomics
• rab GTP-Binding Proteins

Identifiers and source

Literature Corpus work

ee59fc09-7a79-5724-b88e-dae564c0d96a

DOI

10.64898/2025.12.09.693280