Article

Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation

2020-08-25

Abstract excerpt

Leucine-rich repeat kinase 2 (LRRK2), the major causative gene product of autosomal-dominant Parkinson’s disease, is a protein kinase that phosphorylates a subset of Rab GTPases. Since pathogenic LRRK2 mutations increase its ability to phosphorylate Rab GTPases, elucidating the mechanisms of how Rab phosphorylation is regulated by LRRK2 is of great importance. We have previously reported that chloroquine-induced l...

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Literature Corpus work: b63e7b23-6ea4-518a-aa41-4accb918403a
DOI: 10.1101/2020.08.25.267385

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