Article

Immune Checkpoint Activity Regulates Polycystic Kidney Disease Progression

2022-04-24

Abstract excerpt

<h4>ABSTRACT</h4> Innate and adaptive immune cells modulate Autosomal Dominant Polycystic Kidney Disease (ADPKD) severity, a common kidney disease with inadequate treatment options. ADPKD shares parallels with cancer where immune checkpoint inhibitors have been shown to reactivate CD8 + T cells and slow tumor growth. We have shown that, in PKD, CD8 + T cell loss worsens disease. This study used orthologous earl...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ee4a6e8f-b21b-5fa8-95fd-486a071a58f6
DOI: 10.1101/2022.04.24.489306

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immune Checkpoint Activity Regulates Polycystic Kidney Disease ProgressionDOI 10.1101/2022.04.24.489306Read

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.Semantic proximity Read

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney diseaseSemantic proximity Read

<i>Ankhd1</i> enhances polycystic kidney disease development via promoting proliferation and fibrosisSemantic proximity Read

Urinary soluble PD-1 as a biomarker of checkpoint inhibitor-induced acute tubulointerstitial nephritisSemantic proximity Read

The tumor necrosis superfamily member 4-1BBL expressed by tumor cells prevents exhaustion of CD8 T cells in a humanized mouse model of papillary renal cell carcinomaSemantic proximity Read

Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease.Semantic proximity Read

Systems biology approaches toward autosomal dominant polycystic kidney disease (ADPKD)Semantic proximity Read

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networksSemantic proximity Read

c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease.Semantic proximity Read

Anti-Polyamine Therapy Restrains Kidney Cyst Growth in an Orthologous Mouse Model of Autosomal Dominant Polycystic Kidney DiseaseSemantic proximity Read

Therapeutic targets for polycystic kidney disease.Semantic proximity Read

Tubular STAT3 limits renal inflammation in autosomal dominant polycystic kidney diseaseSemantic proximity Read