Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.

Journal of the American Society of Nephrology : JASN - 1 Jan 2021

Zhang Chao, Balbo Bruno, Ma Ming, Zhao Jun, Tian Xin, Kluger Yuval, Somlo Stefan

Abstract excerpt

BACKGROUND: Mutations in PKD1 and PKD2, which encode the transmembrane proteins polycystin-1 and polycystin-2, respectively, cause autosomal dominant polycystic kidney disease (ADPKD). Polycystins are expressed in the primary cilium, and disrupting cilia structure significantly slows ADPKD progression following inactivation of polycystins. The cellular mechanisms of polycystin- and cilia-dependent cyst...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalytic Domain
Share to CDC2 Protein Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Exome Sequencing

Share to Polycystic Kidney, Autosomal Dominant

Share to Pyruvate Dehydrogenase Acetyl-Transferring Kinase

Share to RNA-Seq

Share to TRPP Cation Channels

Source

Open in PubMed Open full text

Identifiers

PMID: 33046531
DOI: 10.1681/ASN.2020040511
PMCID: PMC7894654

Genes

PKD1
PKD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cyclin-Dependent Kinase 1 Activity Is a Driver of Cyst Growth in Polycystic Kidney Disease.PMID 33046531Read ↗

Molecular and cellular pathogenesis of autosomal dominant polycystic kidney disease.Semantic proximity Read ↗

Genetics and Pathogenesis of Polycystic Kidney DiseaseSemantic proximity Read ↗

Polycystic kidney diseases: from molecular discoveries to targeted therapeutic strategies.Semantic proximity Read ↗

Molecular genetics of polycystic kidney disease.Semantic proximity Read ↗

The cell biology of polycystic kidney diseaseSemantic proximity Read ↗

Systems biology of autosomal dominant polycystic kidney disease (ADPKD): computational identification of gene expression pathways and integrated regulatory networksSemantic proximity Read ↗

Autosomal dominant polycystic kidney disease (ADPKD, MIM 173900, PKD1 and PKD2 genes, protein products known as polycystin-1 and polycystin-2).Semantic proximity Read ↗

Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.Semantic proximity Read ↗

Identification of ADPKD-Related Genes and Pathways in Cells Overexpressing PKD2.Semantic proximity Read ↗

The etiology, pathogenesis, and treatment of autosomal dominant polycystic kidney disease: recent advances.Semantic proximity Read ↗

The molecular landscape of polycystic kidneys is marked by common alterations in purine metabolismSemantic proximity Read ↗

Multi-omics profiling of mouse polycystic kidney disease progression at a single cell resolutionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.