c-Jun N-terminal kinase (JNK) signaling contributes to cystic burden in polycystic kidney disease

Abstract excerpt

Polycystic kidney disease is an inherited degenerative disease in which the uriniferous tubules are replaced by expanding fluid-filled cysts that ultimately destroy organ function. Autosomal dominant polycystic kidney disease (ADPKD) is the most common form, afflicting approximately 1 in 1,000 people. It primarily is caused by mutations in the transmembrane proteins polycystin-1 (Pkd1) and polycystin-2 (Pkd2). The...

Topics

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• Cell Proliferation
• Epithelial Cells
• JNK Mitogen-Activated Protein Kinases
• Kidney
• MAP Kinase Signaling System
• Mitogen-Activated Protein Kinase 8
• Polycystic Kidney, Autosomal Dominant
• TRPP Cation Channels

Identifiers and source

Literature Corpus work

f0c45fbd-248e-5089-89aa-5b426db8e52c

DOI

10.1101/2021.07.15.452451