Cellular senescence and its association with aldose reductase promote cyst growth in autosomal dominant polycystic kidney disease.

Abstract excerpt

INTRODUCTION: Autosomal dominant polycystic kidney disease (ADPKD) is one of the most common, life threatening inherited kidney diseases. In the kidney, senescence is accumulated in different renal cells, which are in a state of permanent cell cycle arrest and the development of a senescence-associated secretory phenotype (SASP) in response to stresses. However, the role of cellular senescence in ADPKD remains...

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