Article

Tubular STAT3 limits renal inflammation in autosomal dominant polycystic kidney disease

2019-12-12

Abstract excerpt

<h4>ABSTRACT</h4> The inactivation of the ciliary proteins polycystin 1 or 2 leads to autosomal dominant polycystic kidney disease (ADPKD), the leading genetic cause of chronic kidney disease. Both cilia signaling and interstitial inflammation play a critical role in the disease. Yet, the reciprocal interactions between immune and tubular cells are not well characterized. The transcription factor STAT3, which is...

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Literature Corpus work: a555d8df-7e27-5843-96da-5408ef7dbe73
DOI: 10.1101/2019.12.12.873901

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