Article

The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis

2021-04-26

Abstract excerpt

Given the plasticity of hematopoietic stem/progenitor cells, multiple routes of differentiation must be blocked during acute myeloid leukemia pathogenesis – the molecular basis of which is incompletely understood. Here we report that post-transcriptional repression of transcription factor ARID3A by miR-125b is a key event in megakaryoblastic leukemia (AMKL) pathogenesis. AMKL is frequently associated with trisomy...

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Literature Corpus work: ee31d203-6aba-598f-923c-c5656dadc929
DOI: 10.1101/2021.04.26.440795

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