Article
The megakaryocytic transcription factor ARID3A suppresses leukemia pathogenesis.
Blood - 3 Feb 2022
Alejo-Valle Oriol, Weigert Karoline, Bhayadia Raj, Ng Michelle, Issa Hasan, Beyer Christoph, Emmrich Stephan, Schuschel Konstantin, Ihling Christian, Sinz Andrea, Zimmermann Martin, Wickenhauser Claudia, Flasinski Marius, Regenyi Eniko, Labuhn Maurice, Reinhardt Dirk, Yaspo Marie-Laure, Heckl Dirk, Klusmann Jan-Henning
Abstract excerpt
Given the plasticity of hematopoietic stem and progenitor cells, multiple routes of differentiation must be blocked in the the pathogenesis of acute myeloid leukemia, the molecular basis of which is incompletely understood. We report that posttranscriptional repression of the transcription factor ARID3A by miR-125b is a key event in the pathogenesis of acute megakaryoblastic leukemia (AMKL). AMKL is frequently...
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