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Article

miR-125b-2 is a potential oncomiR on human chromosome 21 in megakaryoblastic leukemia.

Genes & development - 1 Mar 2010

Klusmann Jan-Henning, Li Zhe, Böhmer Katarina, Maroz Aliaksandra, Koch Mia Lee, Emmrich Stephan, Godinho Frank J, Orkin Stuart H, Reinhardt Dirk

Abstract excerpt

Children with trisomy 21/Down syndrome (DS) are at high risk to develop acute megakaryoblastic leukemia (DS-AMKL) and the related transient leukemia (DS-TL). The factors on human chromosome 21 (Hsa21) that confer this predisposing effect, especially in synergy with consistently mutated transcription factor GATA1 (GATA1s), remain poorly understood. Here, we investigated the role of Hsa21-encoded miR-125b-2, a...

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Share to Chromosomes, Human, Pair 21
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Down Syndrome

Share to GATA1 Transcription Factor

Share to Gene Expression Regulation, Leukemic

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Share to Leukemia, Megakaryoblastic, Acute

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Source

Open in PubMed Open full text

Identifiers

PMID: 20194440
DOI: 10.1101/gad.1856210
PMCID: PMC2827843

Genes

DICER1
GATA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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