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Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinib

2025-06-03

Abstract excerpt

Progression of myeloproliferative neoplasms (MPNs) to secondary acute myeloid leukemia (sAML) is a lethal transition lacking reliable early biomarkers and effective therapies. Integrating multi-omics analyses, a cohort of 240 patient biopsies, and functional studies, we identify High Mobility Group A1 (HMGA1) as a critical driver and predictor of this transformation. HMGA1 expression, readily detectable by immunoh...

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Literature Corpus work
33c6d92b-de49-5e1d-b80b-68033929c7b1
DOI
10.1101/2025.06.01.657170
Open publication

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Targeting HMGA1-driven leukemic transformation in myeloproliferative neoplasms with pacritinibDOI 10.1101/2025.06.01.657170
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