Article
Pediatric non-Down syndrome acute megakaryoblastic leukemia is characterized by distinct genomic subsets with varying outcomes.
Nature genetics - 1 Mar 2017
de Rooij Jasmijn D E, Branstetter Cristyn, Ma Jing, Li Yongjin, Walsh Michael P, Cheng Jinjun, Obulkasim Askar, Dang Jinjun, Easton John, Verboon Lonneke J, Mulder Heather L, Zimmermann Martin, Koss Cary, Gupta Pankaj, Edmonson Michael, Rusch Michael, Lim Joshua Yew Suang, Reinhardt Katarina, Pigazzi Martina, Song Guangchun, Yeoh Allen Eng Juh, Shih Lee-Yung, Liang Der-Cherng, Halene Stephanie, Krause Diane S, Zhang Jinghui, Downing James R, Locatelli Franco, Reinhardt Dirk, van den Heuvel-Eibrink Marry M, Zwaan C Michel, Fornerod Maarten, Gruber Tanja A
Abstract excerpt
Acute megakaryoblastic leukemia (AMKL) is a subtype of acute myeloid leukemia (AML) in which cells morphologically resemble abnormal megakaryoblasts. While rare in adults, AMKL accounts for 4-15% of newly diagnosed childhood AML cases. AMKL in individuals without Down syndrome (non-DS-AMKL) is frequently associated with poor clinical outcomes. Previous efforts have identified chimeric oncogenes in a substantial...
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