Article
SON inhibits megakaryocytic differentiation via repressing RUNX1 and the megakaryocytic gene expression program in acute megakaryoblastic leukemia.
Cancer gene therapy - 1 Sept 2021
Vukadin Lana, Kim Jung-Hyun, Park Eun Young, Stone Joshua K, Ungerleider Nathan, Baddoo Melody C, Kong Hyun Kyung, Richard Alexander, Tran Johnny, Giannini Hannah, Flemington Erik K, Lim Ssang-Taek Steve, Ahn Eun-Young Erin
Abstract excerpt
A high incidence of acute megakaryoblastic leukemia (AMKL) in Down syndrome patients implies that chromosome 21 genes have a pivotal role in AMKL development, but the functional contribution of individual genes remains elusive. Here, we report that SON, a chromosome 21-encoded DNA- and RNA-binding protein, inhibits megakaryocytic differentiation by suppressing RUNX1 and the megakaryocytic gene expression program....
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