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Article

Characterization of novel genomic alterations and therapeutic approaches using acute megakaryoblastic leukemia xenograft models

8 Oct 2012

Abstract excerpt

Acute megakaryoblastic leukemia (AMKL) is a heterogeneous disease generally associated with poor prognosis. Gene expression profiles indicate the existence of distinct molecular subgroups, and several genetic alterations have been characterized in the past years, including the t(1;22)(p13;q13) and the trisomy 21 associated with GATA1 mutations. However, the majority of patients do not present with known...

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PMID: 23045605
DOI: 10.1084/jem.20121343

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