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Article

HMGA1 chromatin regulators induce transcriptional networks involved in GATA2 and proliferation during MPN progression

14 Mar 2022

Abstract excerpt

Myeloproliferative neoplasms (MPNs) transform to myelofibrosis (MF) and highly lethal acute myeloid leukemia (AML), although the actionable mechanisms driving progression remain elusive. Here, we elucidate the role of the high mobility group A1 (HMGA1) chromatin regulator as a novel driver of MPN progression. HMGA1 is upregulated in MPN, with highest levels after transformation to MF or AML. To define HMGA1...

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PMID: 35286385
DOI: 10.1182/blood.2021013925

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