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Increased expression of RUNX3 inhibits normal human myeloid development

30 Apr 2022

Abstract excerpt

RUNX3 is a transcription factor dysregulated in acute myeloid leukemia (AML). However, its role in normal myeloid development and leukemia is poorly understood. Here we investigate RUNX3 expression in both settings and the impact of its dysregulation on myelopoiesis. We found that RUNX3 mRNA expression was stable during hematopoiesis but decreased with granulocytic differentiation. In AML, RUNX3 mRNA was...

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PMID: 35490198
DOI: 10.1038/s41375-022-01577-2

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