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A trajectory-coupled network bottleneck governs gemcitabine resistance in 3D PDAC tissue models

2026-03-26

Abstract excerpt

PDAC exhibits rapid chemoresistance, yet how drug-tolerant states arise remains unclear. Existing approaches miss how network topology evolves across cell-state transitions under drug pressure. A 3D PANC-1 tissue model on decellularized intestinal matrix was used for scRNA-seq across four conditions (control, GEM, TGF-β1, GEM+TGF-β1). Pseudotime trajectory inference was combined with dynamic PPI network analysis....

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Literature Corpus work
ee2e950e-1a57-51ae-bc5e-d37991cbad05
DOI
10.64898/2026.03.24.713885
Open publication

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A trajectory-coupled network bottleneck governs gemcitabine resistance in 3D PDAC tissue modelsDOI 10.64898/2026.03.24.713885
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