Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development.

Molecular cancer - 4 Oct 2024

Vasseur Damien, Bigot Ludovic, Beshiri Kristi, Flórez-Arango Juan, Facchinetti Francesco, Hollebecque Antoine, Tselikas Lambros, Aldea Mihaela, Blanc-Durand Felix, Gazzah Anas, Planchard David, Lacroix Ludovic, Pata-Merci Noémie, Nobre Catline, Da Silva Alice, Nicotra Claudio, Ngo-Camus Maud, Braye Floriane, Nikolaev Sergey I, Michiels Stefan, Jules-Clement Gérôme, Olaussen Ken André, André Fabrice, Scoazec Jean-Yves, Barlesi Fabrice, Ponce Santiago, Soria Jean-Charles, Besse Benjamin, Loriot Yohann, Friboulet Luc

Abstract excerpt

BACKGROUND: Understanding the resistance mechanisms of tumor is crucial for advancing cancer therapies. The prospective MATCH-R trial (NCT02517892), led by Gustave Roussy, aimed to characterize resistance mechanisms to cancer treatments through molecular analysis of fresh tumor biopsies. This report presents the genomic data analysis of the MATCH-R study conducted from 2015 to 2022 and focuses on targeted...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged, 80 and over

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biomarkers, Tumor

Share to Drug Resistance, Neoplasm

Share to Exome Sequencing

Share to Mice, SCID

Share to Molecular Targeted Therapy

Share to Neoplasms

Share to Xenograft Model Antitumor Assays

Source

Open in PubMed Open full text

Identifiers

PMID: 39363320
DOI: 10.1186/s12943-024-02134-4
PMCID: PMC11451117

Genes

KRAS
ALK
BRAF
EGFR
FGFR2
AKT1
NF1
NF2
PIK3CA
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Deciphering resistance mechanisms in cancer: final report of MATCH-R study with a focus on molecular drivers and PDX development.PMID 39363320Read ↗

Integrative Pan-Cancer Genomic and Transcriptomic Analyses of Refractory Metastatic CancerSemantic proximity Read ↗

Molecular Mechanisms of Cancer Drug Resistance: Emerging Biomarkers and Promising Targets to Overcome Tumor ProgressionSemantic proximity Read ↗

Integrative pan-cancer genomic and transcriptomic analyses of refractory metastatic cancerSemantic proximity Read ↗

Next-Generation Sequencing-Based Evaluation of the Actionable Mutational Landscape in Solid Tumors: the “MOZART” Prospective Observational StudySemantic proximity Read ↗

Molecular Mechanisms of Targeted Therapy Resistance in Genitourinary Tumors: A Path to New Therapeutic HorizonsSemantic proximity Read ↗

Tumor-Type Agnostic, Targeted Therapies: BRAF Inhibitors Join the Group.Semantic proximity Read ↗

Target-Driven Tissue-Agnostic Drug Approvals; a New Path of Drug DevelopmentSemantic proximity Read ↗

Next-generation sequencing-based evaluation of the actionable landscape of genomic alterations in solid tumors: the "MOZART" prospective observational study.Semantic proximity Read ↗

Molecularly matched therapy in the context of sensitivity, resistance, and safety; patient outcomes in end-stage cancer - the MetAction study.Semantic proximity Read ↗

BRAF inhibitor resistance in melanoma: from resistance mechanisms to therapeutic innovations.Semantic proximity Read ↗

The landscape of drug sensitivity and resistance in sarcomaSemantic proximity Read ↗

Genomic profiling and expanded use of targeted anticancer drugs in solid cancers with exhausted evidence-based treatment options: the PRECODE study protocolSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.