Article
Impact of culture dimensionality and matrix composition on morphology, phenotype and drug response in pancreatic cancer models.
Scientific reports - 14 Apr 2026
Doelvers Florian, Wansch Katharina, Kuehn Anna, Dragomir Mihnea P, Janik Tobias, Joosten Maria, Hilfenhaus Georg, Vecchione Loredana, Felsenstein Matthäus, Ma Dou, Lerchbaumer Markus, Jürgensen Christian, Bahra Marcus, Duwe Gregor, Stintzing Sebastian, Keilholz Ulrich, Pelzer Uwe, Neumann Christopher C M
Abstract excerpt
Patient-derived in vitro systems are powerful preclinical models that replicate key features of human tumors and enable investigation of cancer biology and drug response. They are particularly promising for pancreatic cancer research. We examined whether culture dimensionality and basement membrane extract (BME) composition affect establishment rates, morphology, proliferation, marker expression, and drug...
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