Article

Single-Cell Dissection of Cisplatin-Resistant Muscle-Invasive Bladder Cancer Reveals Adaptive States and Therapeutic Vulnerabilities

2026-08-31

Abstract excerpt

<title>Abstract</title> <p>Background Cisplatin-based chemotherapy remains central for muscle-invasive bladder cancer (MIBC), but acquired resistance frequently limits durable benefit. Resistance evolution may not only reflect loss of platinum sensitivity but also generate adaptive states with therapeutically actionable features. Whether resistant malignant epithelial cells converge into a single drug-tolerant p...

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Literature Corpus work: 5245a737-8f81-5e39-ab2f-82435a8a683e
DOI: 10.21203/rs.3.rs-10668608/v1

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