Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.

doi:10.1038/s41467-019-14224-9

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Article

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRASG13D.

Nature communications - 24 Jan 2020

Kennedy Susan A, Jarboui Mohamed-Ali, Srihari Sriganesh, Raso Cinzia, Bryan Kenneth, Dernayka Layal, Charitou Theodosia, Bernal-Llinares Manuel, Herrera-Montavez Carlos, Krstic Aleksandar, Matallanas David, Kotlyar Max, Jurisica Igor, Curak Jasna, Wong Victoria, Stagljar Igor, LeBihan Thierry, Imrie Lisa, Pillai Priyanka, Lynn Miriam A, Fasterius Erik, Al-Khalili Szigyarto Cristina, Breen James, Kiel Christina, Serrano Luis, Rauch Nora, Rukhlenko Oleksii, Kholodenko Boris N, Iglesias-Martinez Luis F, Ryan Colm J, Pilkington Ruth, Cammareri Patrizia, Sansom Owen, Shave Steven, Auer Manfred, Horn Nicola, Klose Franziska, Ueffing Marius, Boldt Karsten, Lynn David J, Kolch Walter

Abstract excerpt

Protein-protein-interaction networks (PPINs) organize fundamental biological processes, but how oncogenic mutations impact these interactions and their functions at a network-level scale is poorly understood. Here, we analyze how a common oncogenic KRAS mutation (KRASG13D) affects PPIN structure and function of the Epidermal Growth Factor Receptor (EGFR) network in colorectal cancer (CRC) cells. Mapping >6000...

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PMID: 31980649
DOI: 10.1038/s41467-019-14224-9
PMCID: PMC6981206

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