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An integrative ex vivo platform for mapping therapy-induced cellular adaptations in urothelial carcinoma: GLUT1 as an example of chemotherapy-induced metabolic resistance

2026-06-15

Abstract excerpt

<title>Abstract</title> <p>In muscle-invasive bladder cancer (MIBC), the variability in response to systemic treatments and the lack of clinically useful predictive biomarkers highlight the need for approaches that reflect tumor adaptation to therapy, to guide the rational intensification or reduction of treatment in the era of combination therapy. We integrated ex vivo tumor tissue slice cultures with 10x Genomi...

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Literature Corpus work
ecdeacff-5329-53c8-9bbf-5533b78b9b20
DOI
10.21203/rs.3.rs-9879971/v1
Open publication

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An integrative ex vivo platform for mapping therapy-induced cellular adaptations in urothelial carcinoma: GLUT1 as an example of chemotherapy-induced metabolic resistanceDOI 10.21203/rs.3.rs-9879971/v1
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