Comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.

doi:10.1016/j.neurobiolaging.2013.11.015

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Article

Comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.

Neurobiology of aging - 1 May 2014

Trinh Joanne, Amouri Rim, Duda John E, Morley James F, Read Matthew, Donald Alan, Vilariño-Güell Carles, Thompson Christina, Szu Tu Chelsea, Gustavsson Emil K, Ben Sassi Samia, Hentati Emna, Zouari Mourad, Farhat Emna, Nabli Fatma, Hentati Faycel, Farrer Matthew J

Abstract excerpt

Parkinson disease is a progressive neurodegenerative disease for which leucine-rich repeat kinase 2 (LRRK2 carriers) p.G2019S confers substantial genotypic and population attributable risk. With informed consent, we have recruited clinical data from 778 patients from Tunisia (of which 266 have LR...

Topics

Age Factors
Age of Onset
Aged
Case-Control Studies
Cognition
Disease Progression
Female
Humans
Incidence
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2
Male
Middle Aged
Molecular Targeted Therapy

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Motor Activity

Mutation

Parkinson Disease

Protein Serine-Threonine Kinases

Regression Analysis

Source

Open in PubMed

Identifiers

PMID: 24355527
DOI: 10.1016/j.neurobiolaging.2013.11.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-24355527-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.