Article
Comparative study of Parkinson's disease and leucine-rich repeat kinase 2 p.G2019S parkinsonism.
Neurobiology of aging - 1 May 2014
Trinh Joanne, Amouri Rim, Duda John E, Morley James F, Read Matthew, Donald Alan, Vilariño-Güell Carles, Thompson Christina, Szu Tu Chelsea, Gustavsson Emil K, Ben Sassi Samia, Hentati Emna, Zouari Mourad, Farhat Emna, Nabli Fatma, Hentati Faycel, Farrer Matthew J
Abstract excerpt
Parkinson disease is a progressive neurodegenerative disease for which leucine-rich repeat kinase 2 (LRRK2 carriers) p.G2019S confers substantial genotypic and population attributable risk. With informed consent, we have recruited clinical data from 778 patients from Tunisia (of which 266 have LRRK2 parkinsonism) and 580 unaffected subjects. Motor, autonomic, and cognitive assessments in idiopathic Parkinson...
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