Article

The p.Gly2019Ser is the commonest pathogenic mutation in the LRRK2 gene among Egyptians with familial and sporadic Parkinson's disease

2024-07-01

Abstract excerpt

<title>Abstract</title> The impact of <italic>LRRK2</italic> variants on the risk of Parkinson's disease (PD) in Egyptians remains unknown. We examined 1,210 Egyptians (611 PD patients and 599 controls) for 12 <italic>LRRK2</italic> mutations. The p.Gly2019Ser was the only variant detected across Egypt, with a prevalence of 4.1% in sporadic cases, 6.5% in familial cases, and 0.68% in controls. Among p.Gly2019S...

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Literature Corpus work: 05ee2d76-5074-5ce4-bb73-cc1f71eaddac
DOI: 10.21203/rs.3.rs-4456878/v1

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