Article
Worldwide frequency of G2019S LRRK2 mutation in Parkinson's disease: a systematic review.
Parkinsonism & related disorders - 1 May 2010
Correia Guedes L, Ferreira J J, Rosa M M, Coelho M, Bonifati V, Sampaio C
Abstract excerpt
BACKGROUND: The LRRK2 G2019S mutation is the most frequent known cause of familial and sporadic Parkinson's disease. Knowledge of its worldwide frequency distribution is essential for clinical and molecular research as well as genetic counseling. OBJECTIVES: To conduct a systematic review of the reported frequency of G2019S in different populations and to assess critically the quality of the clinical studies....
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