Article

Functional analysis of recurrent non-coding variants in human melanoma

2022-07-02

Abstract excerpt

<h4>ABSTRACT</h4> Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding variants, representing over 99% of total genetic variation, including the well-characterized TERT promoter mutation. However, the compendium of regulatory non-cod...

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Literature Corpus work: ee030401-5adb-51c0-a7cd-0f652ef4b72f
DOI: 10.1101/2022.06.30.498319

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