Article
The search for cis-regulatory driver mutations in cancer genomes.
Oncotarget - 20 Oct 2015
Poulos Rebecca C, Sloane Mathew A, Hesson Luke B, Wong Jason W H
Abstract excerpt
With the advent of high-throughput and relatively inexpensive whole-genome sequencing technology, the focus of cancer research has begun to shift toward analyses of somatic mutations in non-coding cis-regulatory elements of the cancer genome. Cis-regulatory elements play an important role in gene regulation, with mutations in these elements potentially resulting in changes to the expression of linked genes. The...
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