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Article

Functional analysis of recurrent CDC20 promoter variants in human melanoma.

Communications biology - 29 Nov 2023

Godoy Paula M, Oyedeji Abimbola, Mudd Jacqueline L, Morikis Vasilios A, Zarov Anna P, Longmore Gregory D, Fields Ryan C, Kaufman Charles K

Abstract excerpt

Small nucleotide variants in non-coding regions of the genome can alter transcriptional regulation, leading to changes in gene expression which can activate oncogenic gene regulatory networks. Melanoma is heavily burdened by non-coding variants, representing over 99% of total genetic variation, including the well-characterized TERT promoter mutation. However, the compendium of regulatory non-coding variants is...

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Share to Cdc20 Proteins
Share to TERT gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome

Share to Melanoma

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Share to Promoter Regions, Genetic

Share to Regulatory Sequences, Nucleic Acid

Source

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Identifiers

PMID: 38030698
DOI: 10.1038/s42003-023-05526-2
PMCID: PMC10686982

Genes

CDC20
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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