Article
Mutational signatures of de-differentiation in functional non-coding regions of melanoma genomes.
PLoS genetics - 1 Jan 2012
Parker Stephen C J, Gartner Jared, Cardenas-Navia Isabel, Wei Xiaomu, Ozel Abaan Hatice, Ajay Subramanian S, Hansen Nancy F, Song Lingyun, Bhanot Umesh K, Killian J Keith, Gindin Yevgeniy, Walker Robert L, Meltzer Paul S, Mullikin James C, Furey Terrence S, Crawford Gregory E, Rosenberg Steven A, Samuels Yardena, Margulies Elliott H
Abstract excerpt
Much emphasis has been placed on the identification, functional characterization, and therapeutic potential of somatic variants in tumor genomes. However, the majority of somatic variants lie outside coding regions and their role in cancer progression remains to be determined. In order to establish a system to test the functional importance of non-coding somatic variants in cancer, we created a low-passage cell...
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