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Article

Cancer regulatory variation.

Current opinion in genetics & development - 1 Feb 2021

Hennessey Rebecca C, Brown Kevin M

Abstract excerpt

The search for somatic cancer driver genes has largely focused on variants altering protein-coding regions of the genome but as this search has plateaued, there has been increasing interest in understanding how the non-coding portion of the genome regulates genes important for carcinogenesis. The increasing number of tumor whole genome sequences has fueled discoveries of recurrent gene regulatory mutations or...

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PMID: 33422949
DOI: 10.1016/j.gde.2020.11.010

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