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Article

Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.

Molecular cancer research : MCR - 1 Aug 2015

Poulos Rebecca C, Thoms Julie A I, Shah Anushi, Beck Dominik, Pimanda John E, Wong Jason W H

Abstract excerpt

UNLABELLED: With the recent discovery of recurrent mutations in the TERT promoter in melanoma, identification of other somatic causal promoter mutations is of considerable interest. Yet, the impact of sequence variation on the regulatory potential of gene promoters has not been systematically evaluated. This study assesses the impact of promoter mutations on promoter activity in the whole-genome sequenced...

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Source

Identifiers

PMID: 26082173
DOI: 10.1158/1541-7786.MCR-15-0146

Genes

NDUFB9
TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.PMID 26082173Read ↗

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