Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes.

British journal of cancer - 1 Nov 2024

Pudjihartono Michael, Pudjihartono Nicholas, O'Sullivan Justin M, Schierding William

Abstract excerpt

BACKGROUND: To develop targeted treatments, it is crucial to identify the full spectrum of genetic drivers in melanoma, including those in non-coding regions. However, recent efforts to explore non-coding regions have primarily focused on gene-adjacent elements such as promoters and non-coding RNAs, leaving intergenic distal regulatory elements largely unexplored. METHODS: We used Hi-C chromatin contact data from...

Topics

Melanoma
Humans
Promoter Regions, Genetic
Mutation
Gene Expression Regulation, Neoplastic
Cell Line, Tumor

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39367275
DOI: 10.1038/s41416-024-02870-w
PMCID: PMC11555344

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Melanoma-specific mutation hotspots in distal, non-coding, promoter-interacting regions implicate novel candidate driver genes.PMID 39367275Read ↗

Functional analysis of recurrent non-coding variants in human melanomaSemantic proximity Read ↗

Functional analysis of recurrent CDC20 promoter variants in human melanoma.Semantic proximity Read ↗

Mapping chromatin interactions at melanoma susceptibility loci uncovers distant cis-regulatory gene targets.Semantic proximity Read ↗

Clustered somatic mutations are frequent in transcription factor binding motifs within proximal promoter regions in melanoma and other cutaneous malignancies.Semantic proximity Read ↗

Systematic Screening of Promoter Regions Pinpoints Functional Cis-Regulatory Mutations in a Cutaneous Melanoma Genome.Semantic proximity Read ↗

Mapping chromatin interactions at melanoma susceptibility loci and cell-type specific dataset integration uncovers distant gene targets of<i>cis</i>-regulationSemantic proximity Read ↗

Genome-wide analysis of noncoding regulatory mutations in cancer.Semantic proximity Read ↗

Candidate cancer driver mutations in superenhancers and long-range chromatin interaction networksSemantic proximity Read ↗

Large distant deletion disrupts CDKN2A enhancer and predisposes to melanomaSemantic proximity Read ↗

A catalog of <i>cis</i> -regulatory mutations in 12 major cancer typesSemantic proximity Read ↗

Landscape of enhancer disruption and functional screen in melanoma cells.Semantic proximity Read ↗

Intergenic disease-associated regions are abundant in novel transcripts.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.