Back to search

Article

Mitochondrial type II NADH dehydrogenase of <i>Plasmodium falciparum</i> is dispensable and not the functional target of putative NDH2 quinolone inhibitors

2018-10-05

Abstract excerpt

The battle against malaria has been substantially impeded by the recurrence of drug resistance in Plasmodium falciparum , the deadliest human malaria parasite. To counter the problem, novel antimalarial drugs are urgently needed, especially those that target unique pathways of the parasite, since they are less likely to have side effects. The mitochondrial type II NADH dehydrogenase of P. falciparum , PfNDH2 (PF...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
ede17fd8-2246-5307-881c-f66b133b0a21
DOI
10.1101/436881
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Mitochondrial type II NADH dehydrogenase of <i>Plasmodium falciparum</i> is dispensable and not the functional target of putative NDH2 quinolone inhibitorsDOI 10.1101/436881
Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stagesSemantic proximity
Function of the alternative electron transport chain in the <i>Cryptosporidium parvum</i> mitosomeSemantic proximity
Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I.Semantic proximity
Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes <i>Cryptosporidium</i> to clofazimine resistanceSemantic proximity
Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.Semantic proximity
'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.Semantic proximity
Genetic analysis of pyrimidine biosynthetic enzymes in <i>Plasmodium falciparum</i>Semantic proximity
Reconstituted ferredoxin-MEP pathway of Apicomplexa in Escherichiacoli as an in situ screening platform for inhibitors and essential enzyme mutations.Semantic proximity
Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functionsSemantic proximity
Biogenesis of cytochromes <i>c</i> and <i>c</i> <sub>1</sub> in the electron transport chain of malaria parasitesSemantic proximity
Host metabolic pathways essential for malaria and related hemoparasites in the infection of nucleated cellsSemantic proximity
Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functionsSemantic proximity
Select a neighboring publication to make it the new centre.