Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functions

9 Apr 2020

Abstract excerpt

The mitochondrion of malaria parasites contains several clinically validated drug targets. Within Plasmodium spp., the causative agents of malaria, the mitochondrial DNA (mtDNA) is only 6 kb long, being the smallest mitochondrial genome among all eukaryotes. The mtDNA encodes only three proteins of the mitochondrial electron transport chain and ∼27 small, fragmented rRNA genes having lengths of 22–195...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Hepatitis C virus research
Share to Malaria Research and Control
Share to Mosquito-borne diseases and control

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32273345
DOI: 10.1074/jbc.ra120.012646

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic ablation of the mitoribosome in the malaria parasite Plasmodium falciparum sensitizes it to antimalarials that target mitochondrial functionsPMID 32273345Read ↗

Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functionsSemantic proximity Read ↗

The mitochondrial ribosomal protein L13 is critical for the structural and functional integrity of the mitochondrion in Plasmodium falciparumSemantic proximity Read ↗

Transcriptional changes in Plasmodium falciparum upon conditional knock down of mitochondrial ribosomal proteins RSM22 and L23Semantic proximity Read ↗

Identification and Validation of Toxoplasma gondii Mitoribosomal Large Subunit ComponentsSemantic proximity Read ↗

Mitochondrial Drug Targets in Apicomplexan ParasitesSemantic proximity Read ↗

The Diseased Mitoribosome.Semantic proximity Read ↗

A mutagenesis screen for essential plastid biogenesis genes in human malaria parasitesSemantic proximity Read ↗

Divergent Mitochondrial Ribosomes in Unicellular Parasitic Protozoans.Semantic proximity Read ↗

Targeting the apicoplast in malariaSemantic proximity Read ↗

Human Mitoribosome Biogenesis and Its Emerging Links to Disease.Semantic proximity Read ↗

Functional genomics of RAP proteins and their role in mitoribosome regulation in Plasmodium falciparumSemantic proximity Read ↗

ATAD3 megadalton complex in <i>Plasmodium falciparum</i> is essential for mitochondrial and cellular viabilitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.