Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I.

Proceedings of the National Academy of Sciences of the United States of America - 19 Oct 2021

Duarte Margarida, Ferreira Cleide, Khandpur Gurleen Kaur, Flohr Tamara, Zimmermann Jannik, Castro Helena, Herrmann Johannes M, Morgan Bruce, Tomás Ana M

Abstract excerpt

Type II NADH dehydrogenases (NDH2) are monotopic enzymes present in the external or internal face of the mitochondrial inner membrane that contribute to NADH/NAD+ balance by conveying electrons from NADH to ubiquinone without coupled proton translocation. Herein, we characterize the product of a gene present in all species of the human protozoan parasite Leishmania as a bona fide, matrix-oriented, type II NADH...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport
Share to Electron Transport Complex I

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leishmania

Share to Leishmaniasis

Share to Mutation

Share to NADH Dehydrogenase

Share to Oxidation-Reduction

Share to Research on Leishmaniasis Studies

Source

Open in PubMed Open full text

Identifiers

PMID: 34654744
DOI: 10.1073/pnas.2103803118
PMCID: PMC8545495

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Leishmania type II dehydrogenase is essential for parasite viability irrespective of the presence of an active complex I.PMID 34654744Read ↗

Mitochondrial type II NADH dehydrogenase of <i>Plasmodium falciparum</i> is dispensable and not the functional target of putative NDH2 quinolone inhibitorsSemantic proximity Read ↗

Mitochondrial type II NADH dehydrogenase of Plasmodium falciparum (PfNDH2) is dispensable in the asexual blood stagesSemantic proximity Read ↗

NADH dehydrogenase of Trypanosoma brucei is important for efficient acetate production in bloodstream forms.Semantic proximity Read ↗

The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.Semantic proximity Read ↗

Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II.Semantic proximity Read ↗

'Tethering' fragment-based drug discovery to identify inhibitors of the essential respiratory membrane protein type II NADH dehydrogenase.Semantic proximity Read ↗

Mitochondria in malaria and related parasites: ancient, diverse and streamlinedSemantic proximity Read ↗

Function of the alternative electron transport chain in the <i>Cryptosporidium parvum</i> mitosomeSemantic proximity Read ↗

Redesigned and reversed: architectural and functional oddities of the trypanosomal ATP synthaseSemantic proximity Read ↗

The NADH:ubiquinone oxidoreductase (complex I) of respiratory chains.Semantic proximity Read ↗

Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes <i>Cryptosporidium</i> to clofazimine resistanceSemantic proximity Read ↗

Sterol 14-α-demethylase is vital for mitochondrial functions and stress tolerance in <i>Leishmania major</i>Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.