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Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes <i>Cryptosporidium</i> to clofazimine resistance

2025-10-07

Abstract excerpt

The parasite Cryptosporidium is a leading cause of life-threatening diarrheal disease, and effective treatment is not available. The discovery of potent anti- Cryptosporidium activity of clofazimine, offered the opportunity to repurpose a drug already used to treat leprosy and tuberculosis. However, clofazimine failed in a human trial, which was attributed to poor bioavailability. Here, we observed differential...

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Literature Corpus work
c0bc4069-6340-57c0-b219-90036765114f
DOI
10.1101/2025.10.07.680968
Open publication

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Widespread genomic heterogeneity at the type II NAD(P)H dehydrogenase locus predisposes <i>Cryptosporidium</i> to clofazimine resistanceDOI 10.1101/2025.10.07.680968
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