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Article

Selection of Plasmodium falciparum cytochrome B mutants by putative PfNDH2 inhibitors.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jun 2018

Lane Kristin D, Mu Jianbing, Lu Jinghua, Windle Sean T, Liu Anna, Sun Peter D, Wellems Thomas E

Abstract excerpt

Malaria control is threatened by a limited pipeline of effective pharmaceuticals against drug-resistant strains of Plasmodium falciparum Components of the mitochondrial electron transport chain (ETC) are attractive targets for drug development, owing to exploitable differences between the parasite and human ETC. Disruption of ETC function interferes with metabolic processes including de novo pyrimidine synthesis,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29844160
DOI: 10.1073/pnas.1804492115
PMCID: PMC6004454

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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