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Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functions

2020-01-14

Abstract excerpt

<h4>ABSTRACT</h4> The mitochondrion of malaria parasites contains clinically validated drug targets. Within Plasmodium spp ., the mitochondrial DNA (mtDNA) is only 6 kb long, being the smallest mitochondrial genome among all eukaryotes. The mtDNA encodes only three proteins of the mitochondrial electron transport chain and ∼ 27 small, fragmented rRNA genes in length of 22-195 nucleotides. The rRNA fragments are...

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Literature Corpus work
82751735-5a8e-5b80-8d5e-0c38e08986ec
DOI
10.1101/2020.01.14.906198
Open publication

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Genetic ablation of the mitochondrial ribosome in <i>Plasmodium falciparum</i> sensitizes the human malaria parasite to antimalarial drugs targeting mitochondrial functionsDOI 10.1101/2020.01.14.906198
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